Aubameyang suffers fresh setback due to heart problems
Aubameyang had recently tested positive for Covid-19 but had been expected to be involved in the clash after returning to training.
However, the striker was ultimately ruled out of the game along with Axel Meye and Mario Lemina.
A statement from the Ghana FA reads: "According to the CAF medical commission, the players Pierre-Emerick Aubameyang, Axel Meyé and Mario Lemina barely out of the Covid cannot take part in this match. The examinations would show heart problems. CAF did not want to take any risks."
Aubameyang has been going through a turbulent period in his career, during which he lost the Arsenal captaincy due to ill discipline.
His last appearance for the club came on 6 December in a 2-1 away loss against Everton, with the Gabon star subsequently missing a four-match winning run in the league, during which Mikel Arteta's side scored 14 goals.
The fallout from his actions had led to a widespread acceptance that he was liable to depart in January.
Barcelona were initially mentioned as potential suitors but ultimately opted for the younger Ferran Torres instead. Meanwhile, Juventus have since come onto the scene, with Aubameyang touted as a potential replacement for the long-term injured Federico Chiesa.
With a contract that expires in 2023 and his stock at Arsenal dropping, his future appears to be away from the club.
Aubameyang's heart issue, though, clearly represents a hindrance to any deal taking place this month, with the health and wellbeing of the player absolutely paramount to all involved.
Aubameyang has been at Arsenal since joining from Dortmund in 2018 and has scored 92 goals in 163 outings for the Emirates club.